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KMID : 0360419800160020001
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Korean Journal of Pharmacology
1980 Volume.16 No. 2 p.1 ~ p.7
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Influence of Intracerebroventricular Nalorphine on the Renal Function of the Rabbit
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Abstract
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As it has been reported that morphine induce antidiuresis, and antinatriuresis along with decrease in renal hemodynamics when given intracerebroventricularly[ivt], the renal action of nalorphine, a partial antagonist of morphine action, and its influence upon the morphine action were investigated in this study.
10 ㎍/kg of nalorphine given into the lateral ventricle of the rabbit brain tended to decrease renal plasma flow and glomerular filtration rate and increase the reabsorption of free water in the tubules. 100㎍/kg ivt significantly decreased urine flow rate and increased free water reabsorption, and tended to increase electrolyte excretion in spite of decrease in renal plasma flow and glomerular filtration, suggesting that ADH also involved in the antidiuresis.
Morphine hydrochloride, 10 ㎍/kg, ivt, produced marked decrement in renal hemodynamics along with decreased excretions of sodium, potassium and water, and these morphine actions were alleviated by nalorphine given 20 min later. The natriuretic action of ivt nalorphine manifested itself uninfluenced by the morphine.
These observations indicate that nalorphine ivt produces renal actions similar to those of morphine, though less potent, and that it can antagonize the latter action. It is suggested that morphine influences renal hemodynamics through nerve by stimulating the "morphine receptor" in the brain, whereas nalorphine liberates ADH by the agonistic action on the "nalorphine receptor".
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